The National Science Foundation’s (NSF) newly established Directorate for Technology, Innovation, and Partnerships (TIP) announces the NSF Regional Innovation Engines (NSF Engines) program. This program is a bold new initiative aimed at significantly expanding our Nation’s innovation capacity by investing in key areas of national interest and economic promise in every region of the United States. The NSF Engines program provides up to 10 years of funding to establish each Engine, with up to an additional two years of development funding even before the official launch of an Engine. Each NSF Engine can receive up to $160 million to support the development of diverse regional coalitions to engage in use-inspired research and development, translation of innovation to society, and workforce development — with the goal of growing and sustaining regional innovation ecosystems throughout the U.S. Prior to submission of proposals, teams are required to submit a Concept Outline, which is due: June 30, 2022.